In a near future, the zombies are all around the world, and the human society is restructured and adapted for the new reality. In a protected city ruled by the powerful Kaufman (Dennis Hopper), the upper class has the usual privileges living in a fancy well-supplied building, while the poor people lives on the streets. Riley (Simon Baker) and Cholo (John Leguizamo) belong to a team that bring supplies (food, medicine etc.) to the city using a heavy truck called Dead Reckoning and designed by Riley. When Cholo is betrayed by Kaufman, he steals the Dead Reckoning and threatens Kaufman, who requests Riley to retrieve the vehicle, with the support of his friend Charlie (Robert Joy) and Slack (Asia Argento). But the dead are smarter and organized under the leadership of Big Daddy (Eugene Clark).